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Well-known for its authoritative and comprehensive coverage, complete treatment of pediatric pathophysiology, and the most extensive illustration program in its field, this textbook features expert content on everything from the general principles of pathophysiology to detailed discussions of genetics and specific diseases. Chapters on alteration present the pathophysiology, clinical manifestations, and evaluation and treatment of each disease to help you learn to identify normal anatomy and physiology, as well as alterations of function in adults and in children.- Unparalleled coverage of disease processes makes this text the most comprehensive pathophysiology text available.
- The largest full-color art program in the field illustrates the clinical manifestations of diseases and disease processes
- Consistent presentations of each disease with pathophysiology, clinical manifestations, and evaluation and treatment help you find the information you need quickly and easily.
- Ten separate pediatric chapters cover the pathophysiologic effects on children.
- Aging content is highlighted throughout the text.
- An Introduction to Pathophysiology section at the beginning of the text provides a solid start to the basics of the study of disease.
- Algorithms and flowcharts of diseases and disorders illustrate the disease process in an easy-to-understand format.
- Nutrition and Disease boxes present evidence-based information on the relationship between health promotion through diet and disease.
- Updated content on leukocytes in pain modulation, seizure disorders, brain injuries and disorders, acute encephalopathies, reproductive disorders, and much more keep you at the cutting edge of this constantly changing field.
- What’s New? boxes highlight the most current research and findings to ensure you have the most up-to-date information.
- New animations, review questions, Key Points, and an audio glossary have been added to the Evolve companion website to strengthen your understanding of key concepts.
- Media Resources Lists encourage you to develop a study plan to master the important content in each chapter.

Table of Content:
PART ONE: CENTRAL CONCEPTS OF PATHOPHYSIOLOGY: CELLS AND TISSUESUnit I: The Cell
1.Cellular Biology
2.Altered Cellular and Tissue Biology
3.The Cellular Environment: Fluids and Electrolytes, Acids and Bases
Unit II: Genes and Gene-Environment Interaction
4.Genes and Genetic Diseases
5.Genes, Environment, Life-style, and Common Diseases
Unit III: Mechanisms of Self-Defense
6.Innate Immunity: Inflammation
7.Adaptive Immunity
8.Alterations in Immunity and Inflammation
9.Infection
10.Stress and Disease
Unit IV: Cellular Proliferation: Cancer
11.Biology, Clinical Manifestations, and Treatment of Cancer
12.Cancer Epidemiology
13.Cancer in Children
PART TWO: PATHOPHYSIOLOGIC ALTERATIONS: ORGANS AND SYSTEMS
Unit V: The Neurologic System
14.Structure and Function of the Neurologic System
15.Pain, Temperature Regulation, Sleep, and Sensory Function
16.Alterations in Cognitive Systems, Cerebral Hemodynamics and Motor Function
17.Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction
18.Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders
19.Alterations of Neurologic Function in Children
Unit VI: The Endocrine System
20.Mechanisms of Hormonal Regulation
21.Alterations of Hormonal Regulation
Unit VII: The Reproductive Systems
22.Structure and Function of the Reproductive Systems
23.Alterations of the Reproductive Systems
24.Sexually Transmitted Infections
Unit VIII: The Hematologic System
25.Structure and Function of the Hematologic System
26.Alterations of Erythrocyte Function
27.Alterations of Leukocyte, Lymphoid, and Hemostatic Function
28.Alterations of Hematologic Function in Children
Unit IX: The Cardiovascular and Lymphatic Systems
29.Structure and Function of the Cardiovascular and Lymphatic Systems
30.Alterations of Cardiovascular Function
31.Alterations of Cardiovascular Function in Children
Unit X: The Pulmonary System
32.Structure and Function of the Pulmonary System
33.Alterations of Pulmonary Function
34.Alterations of Pulmonary Function in Children
Unit XI: The Renal and Urologic System
35.Structure and Function of the Renal and Urologic Systems
36.Alterations of Renal and Urinary Tract Function
37.Alterations of Renal and Urinary Tract Function in Children
Unit XII: The Digestive System
38.Structure and Function of the Digestive System
39.Alterations of Digestive Function
40.Alterations of Digestive Function in Children
Unit XIII: The Musculoskeletal System
41.Structure and Function of the Musculoskeletal System
42.Alterations of Musculoskeletal Function
43.Alterations of Musculoskeletal Function in Children
Unit XIV: The Integumentary System
44.Structure, Function, and Disorders of the Integument
45.Alterations of the Integument in Children
Unit XV: Multiple Interacting Systems
46.Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults
47.Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children
Product details:
Language: EnglishISBN-10: 0323065848
ISBN-13: 978-0323065849
ISBN-13: 9780323065849
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